A-Kinase Anchor Protein 6 (AKAP6) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
A-Kinase Anchor Protein 6 (AKAP6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431777
tested applications
P-ELISA, WB
Description
AKAP6 Antibody is a Goat Polyclonal antibody against AKAP6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 6 (AKAP6) |
| Host | Goat |
| Reactivity | Mouse |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 9472, 238161, 64553 |
| NCBI Accession | NP_004265.3 |
| Alias | AKAP6, AKAP100, KIAA0311 |
| Background | Antibody anti-AKAP6 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
AKAP6, also known as mAKAP (muscle AKAP), is a scaffold protein predominantly expressed in cardiac and skeletal muscle cells. It anchors PKA and other signaling molecules, such as phosphodiesterases (PDEs) and calcium-handling proteins, to the nuclear envelope, creating a signaling hub that regulates hypertrophic responses, calcium dynamics, and transcription. AKAP6 is critical for cardiomyocyte function, as it spatially coordinates cAMP signaling and calcium release to control excitation-contraction coupling and cardiac remodeling under stress. It interacts with PDE4D to regulate local cAMP levels and prevent hyperactivation of PKA, ensuring precise signaling. Mutations or dysfunctions in AKAP6 are associated with pathological cardiac hypertrophy and heart failure. Additionally, AKAP6 integrates signals from beta-adrenergic receptors, impacting gene transcription through interactions with nuclear factor NFAT and histone deacetylases. AKAP6’s unique role in organizing nuclear and perinuclear signaling makes it vital for cardiac development and adaptive responses to physiological stress.
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