A-Kinase Anchoring Protein 6 (AKAP6) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
A-Kinase Anchoring Protein 6 (AKAP6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx211407
tested applications
ELISA, IHC
Description
AKAP6 Antibody is a Rabbit Polyclonal against AKAP6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchoring Protein 6 (AKAP6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/3000 - 1/10000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13023 |
| Gene ID | 9472 |
| Alias | AKAP6, AKAP100, KIAA0311 |
| Background | Antibody anti-AKAP6 |
| Status | RUO |
Descripción
AKAP6, also known as mAKAP (muscle AKAP), is a scaffold protein predominantly expressed in cardiac and skeletal muscle cells. It anchors PKA and other signaling molecules, such as phosphodiesterases (PDEs) and calcium-handling proteins, to the nuclear envelope, creating a signaling hub that regulates hypertrophic responses, calcium dynamics, and transcription. AKAP6 is critical for cardiomyocyte function, as it spatially coordinates cAMP signaling and calcium release to control excitation-contraction coupling and cardiac remodeling under stress. It interacts with PDE4D to regulate local cAMP levels and prevent hyperactivation of PKA, ensuring precise signaling. Mutations or dysfunctions in AKAP6 are associated with pathological cardiac hypertrophy and heart failure. Additionally, AKAP6 integrates signals from beta-adrenergic receptors, impacting gene transcription through interactions with nuclear factor NFAT and histone deacetylases. AKAP6’s unique role in organizing nuclear and perinuclear signaling makes it vital for cardiac development and adaptive responses to physiological stress.
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