Human A Kinase Anchor Protein 12 (AKAP12) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human A Kinase Anchor Protein 12 (AKAP12) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx165951
Tested Applications
WB, SDS-PAGE
Description
Human A Kinase Anchor Protein 12 (AKAP12) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | A Kinase Anchor Protein 12 (AKAP12) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Pro1485-Ser1782 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 36.0 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02952 |
| Alias | AKAP250,SSeCKS |
| Background | Protein AKAP12 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
AKAP12, also known as gravin, is a multifunctional scaffold protein that binds PKA, PKC, and other kinases, organizing signaling pathways at the plasma membrane and cytoskeleton. AKAP12 plays a critical role in cell adhesion, migration, and proliferation by coordinating cAMP and PKC signaling in focal adhesions. It regulates cytoskeletal remodeling and cell polarity by interacting with actin-binding proteins, influencing processes like wound healing and cancer metastasis. AKAP12 acts as a tumor suppressor in various cancers, where its loss leads to dysregulated signaling pathways, including ERK/MAPK and cell cycle progression. AKAP12 is also involved in vascular homeostasis, where it regulates endothelial barrier function and angiogenesis. Studies highlight AKAP12’s role in stress responses, particularly in regulating PKA signaling during inflammation and oxidative stress. Additionally, AKAP12 expression is regulated by epigenetic mechanisms, such as promoter methylation, which contributes to its silencing in cancer cells.
Productos relacionados
A Kinase Anchor Protein 12 (AKAP12) Antibody
A Kinase Anchor Protein 12 Antibody is a Rabbit Polyclonal against A Kinase Anchor Protein 12.…
Ver producto Human A Kinase Anchor Protein 12 (AKAP12) Protein
Human A Kinase Anchor Protein 12 (AKAP12) is a recombinant Human protein expressed in E. coli.…
Ver producto
A Kinase Anchor Protein 12 (AKAP12) Antibody
AKAP12 Antibody is a Rabbit Polyclonal against AKAP12.…
Ver producto