AKAP12 antibody
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935106861
info@markelab.com
name
AKAP12 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00252
tested applications
ELISA, WB, IHC
Description
Anchoring protein that mediates the subcellular compartmentation of protein kinase A(PKA) and protein kinase C(PKC).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A kinase(PRKA) anchor protein 12 (AKAP12) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 191 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q02952 |
| Gene ID | 9590 |
| Alias | AKAP250,SSeCKS |
| Background | Antibody anti-AKAP12 |
| Status | RUO |
| Note | Mol. Weight 191 kDa |
Descripción
AKAP12, also known as gravin, is a multifunctional scaffold protein that binds PKA, PKC, and other kinases, organizing signaling pathways at the plasma membrane and cytoskeleton. AKAP12 plays a critical role in cell adhesion, migration, and proliferation by coordinating cAMP and PKC signaling in focal adhesions. It regulates cytoskeletal remodeling and cell polarity by interacting with actin-binding proteins, influencing processes like wound healing and cancer metastasis. AKAP12 acts as a tumor suppressor in various cancers, where its loss leads to dysregulated signaling pathways, including ERK/MAPK and cell cycle progression. AKAP12 is also involved in vascular homeostasis, where it regulates endothelial barrier function and angiogenesis. Studies highlight AKAP12’s role in stress responses, particularly in regulating PKA signaling during inflammation and oxidative stress. Additionally, AKAP12 expression is regulated by epigenetic mechanisms, such as promoter methylation, which contributes to its silencing in cancer cells.
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