Human A Kinase Anchor Protein 1 (AKAP1) ELISA Kit
546€ (96 tests)
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name
Human A Kinase Anchor Protein 1 (AKAP1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx351237
tested applications
ELISA
Description
Human A Kinase Anchor Protein 1 (AKAP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human A Kinase Anchor Protein 1 (AKAP1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A Kinase Anchor Protein 1 (AKAP1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Sensitivity | 0.38 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q92667 |
| Alias | AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1 |
| Background | Elisa kits for AKAP1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP1 is a mitochondrial scaffold protein that anchors Protein Kinase A (PKA) and other signaling molecules to the outer mitochondrial membrane, regulating mitochondrial dynamics, energy production, and apoptosis. AKAP1 modulates mitochondrial membrane potential by organizing signaling complexes involving PKA, phosphatases, and other enzymes. It plays a significant role in cardiomyocyte survival, as it enhances mitochondrial respiration under stress by promoting ATP synthesis. AKAP1 is also involved in the regulation of mitochondrial fission and fusion through interactions with Drp1 and MFN2, thereby maintaining mitochondrial homeostasis. Loss of AKAP1 disrupts mitochondrial function and increases susceptibility to oxidative stress, contributing to neurodegeneration and heart failure. AKAP1 also regulates reactive oxygen species (ROS) production, influencing cellular aging and survival signaling pathways like AMPK. Recent studies have linked AKAP1 downregulation with metabolic disorders and impaired endothelial function, highlighting its role in vascular biology.
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