A Kinase Anchor Protein 1 (AKAP1) Antibody
221€ (50 µg)
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Name
A Kinase Anchor Protein 1 (AKAP1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx324938
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
AKAP1 Antibody is a Rabbit Polyclonal against AKAP1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A Kinase Anchor Protein 1 (AKAP1) Immunogen: Synthesized peptide derived from the Internal region of human AKAP 149. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92667 |
| Gene ID | 8165 |
| Alias | AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1 |
| Background | Antibody anti-AKAP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKAP1 is a mitochondrial scaffold protein that anchors Protein Kinase A (PKA) and other signaling molecules to the outer mitochondrial membrane, regulating mitochondrial dynamics, energy production, and apoptosis. AKAP1 modulates mitochondrial membrane potential by organizing signaling complexes involving PKA, phosphatases, and other enzymes. It plays a significant role in cardiomyocyte survival, as it enhances mitochondrial respiration under stress by promoting ATP synthesis. AKAP1 is also involved in the regulation of mitochondrial fission and fusion through interactions with Drp1 and MFN2, thereby maintaining mitochondrial homeostasis. Loss of AKAP1 disrupts mitochondrial function and increases susceptibility to oxidative stress, contributing to neurodegeneration and heart failure. AKAP1 also regulates reactive oxygen species (ROS) production, influencing cellular aging and survival signaling pathways like AMPK. Recent studies have linked AKAP1 downregulation with metabolic disorders and impaired endothelial function, highlighting its role in vascular biology.
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