A Kinase Anchor Protein 1 (AKAP1) Antibody
52€ (10 µg)
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Name
A Kinase Anchor Protein 1 (AKAP1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx013731
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
Rabbit polyclonal antibody against AKAP1 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A Kinase Anchor Protein 1 (AKAP1) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human AKAP1. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/500, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92667 |
| Alias | AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1 |
| Background | Antibody anti-AKAP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKAP1 is a mitochondrial scaffold protein that anchors Protein Kinase A (PKA) and other signaling molecules to the outer mitochondrial membrane, regulating mitochondrial dynamics, energy production, and apoptosis. AKAP1 modulates mitochondrial membrane potential by organizing signaling complexes involving PKA, phosphatases, and other enzymes. It plays a significant role in cardiomyocyte survival, as it enhances mitochondrial respiration under stress by promoting ATP synthesis. AKAP1 is also involved in the regulation of mitochondrial fission and fusion through interactions with Drp1 and MFN2, thereby maintaining mitochondrial homeostasis. Loss of AKAP1 disrupts mitochondrial function and increases susceptibility to oxidative stress, contributing to neurodegeneration and heart failure. AKAP1 also regulates reactive oxygen species (ROS) production, influencing cellular aging and survival signaling pathways like AMPK. Recent studies have linked AKAP1 downregulation with metabolic disorders and impaired endothelial function, highlighting its role in vascular biology.
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