Human 5-hydroxytryptamine receptor 3C (HTR3C) ELISA Kit
715€ (96 tests)
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935106861
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name
Human 5-hydroxytryptamine receptor 3C (HTR3C) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500209
tested applications
ELISA
Description
Human 5-hydroxytryptamine receptor 3C (HTR3C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human 5-hydroxytryptamine receptor 3C (HTR3C) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 5-hydroxytryptamine receptor 3C (HTR3C) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8WXA8 |
| OMIM | 610121 |
| Alias | HTR3C,5-HT3C receptor |
| Background | Elisa kits for HTR3C |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HTR3C is a subunit that combines with HTR3A to form functional heteromeric 5-HT3 ion channels, which mediate serotonin-induced depolarization in neurons. Unlike HTR3A, HTR3C alone cannot form functional receptors but instead modifies the biophysical properties of the channel when co-assembled with HTR3A. HTR3C is expressed in the gastrointestinal tract and regions of the central nervous system, where it contributes to the regulation of nausea, pain signaling, and gastrointestinal motility. Studies suggest that genetic variations in the HTR3C gene influence susceptibility to functional gastrointestinal disorders, including IBS and visceral hypersensitivity. Although HTR3C's expression is lower than other 5-HT3 receptor subunits, its modulatory role remains significant for understanding serotonin's effects on neurotransmission and peripheral tissues. The HTR3C subunit broadens the diversity of receptor functions, influencing pharmacological responses to 5-HT3 antagonists like ondansetron and granisetron, which are widely used to manage nausea and vomiting.
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