5-Hydroxytryptamine Receptor 3C (HTR3C) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 3C (HTR3C) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032675
tested applications
ELISA, WB
Description
HTR3C Antibody is a Rabbit Polyclonal antibody against HTR3C.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 5-Hydroxytryptamine Receptor 3C (HTR3C) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WXA8 |
| Alias | HTR3C,5-HT3C receptor |
| Background | Antibody anti-HTR3C |
| Status | RUO |
Descripción
HTR3C is a subunit that combines with HTR3A to form functional heteromeric 5-HT3 ion channels, which mediate serotonin-induced depolarization in neurons. Unlike HTR3A, HTR3C alone cannot form functional receptors but instead modifies the biophysical properties of the channel when co-assembled with HTR3A. HTR3C is expressed in the gastrointestinal tract and regions of the central nervous system, where it contributes to the regulation of nausea, pain signaling, and gastrointestinal motility. Studies suggest that genetic variations in the HTR3C gene influence susceptibility to functional gastrointestinal disorders, including IBS and visceral hypersensitivity. Although HTR3C's expression is lower than other 5-HT3 receptor subunits, its modulatory role remains significant for understanding serotonin's effects on neurotransmission and peripheral tissues. The HTR3C subunit broadens the diversity of receptor functions, influencing pharmacological responses to 5-HT3 antagonists like ondansetron and granisetron, which are widely used to manage nausea and vomiting.
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