Human 5-Hydroxytryptamine Receptor 1B / 5-HT1B (HTR1B) ELISA Kit

Product specifications

ELISA Kits

5-Hydroxytryptamine Receptor 1B / 5-HT1B (HTR1B)

Human

Colorimetric

Quantitative

Sandwich

78 pg/ml - 5000 pg/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P28222

HTR1B,S12, 5-HT1B,HTR1D2, HTR1DB, 5-HT-1B, 5-HT1DB, 5-HT-1D-beta,5-HT1B receptor

Elisa kits for HTR1B

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

HTR1B, a subtype of the serotonin receptor family, is a G protein-coupled receptor (GPCR) responsible for mediating the effects of serotonin (5-HT), a neurotransmitter involved in mood, aggression, appetite, and sleep regulation. HTR1B is primarily expressed in the basal ganglia, hippocampus, cortex, and dorsal raphe nucleus, where it functions as both a presynaptic autoreceptor and a postsynaptic receptor. As an autoreceptor, HTR1B inhibits the release of serotonin, thereby regulating its availability at synapses. This negative feedback mechanism is critical for maintaining serotonin homeostasis and preventing overstimulation of neurons. HTR1B also modulates the release of other neurotransmitters, such as dopamine and acetylcholine, contributing to its role in motor control, mood stabilization, and reward pathways. Dysregulation of HTR1B has been implicated in mood disorders, such as depression, anxiety, and aggressive behaviors, as well as conditions like migraine headaches and substance abuse disorders. Pharmacological targeting of HTR1B, particularly through agonists or antagonists, has shown potential in alleviating symptoms of depression, migraine, and other serotonin-related disorders. Its role in modulating synaptic plasticity, neuroprotection, and neuronal signaling makes HTR1B a critical target for understanding and treating neuropsychiatric conditions.

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