Human 14-3-3 Gamma (YWHAG) Protein

Product specifications

Proteins and Peptides

14-3-3 Gamma (YWHAG)

E. coli

Optimal dilutions/concentrations should be determined by the end user.

Human

Unconjugated

Recombinant

10 µg

100 µg

1 mg

Liquid 

SDS-PAGE

Shipped within 10-20 working days.

Aliquot and store at -20 °C.

No

P61981 

YWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, EIEE56, DEE56

Protein YWHAG

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

YWHAG is a key adaptor protein that regulates cellular signaling by interacting with phosphorylated proteins, stabilizing complexes, and controlling their subcellular localization. It participates in pathways such as PI3K/Akt, MAPK, and p53 signaling, where it regulates cell cycle progression, apoptosis, and DNA damage response. YWHAG is highly expressed in neuronal tissues and plays essential roles in synaptic plasticity, neurogenesis, and axonal growth. It also participates in stress response pathways by stabilizing proteins involved in cellular repair and survival. Dysregulation of YWHAG has been implicated in neurodegenerative diseases, including Alzheimer’s and Huntington’s disease, where abnormal interactions lead to protein aggregation and neuronal dysfunction. Additionally, it is overexpressed in various cancers, contributing to tumor progression, resistance to apoptosis, and metastasis. Knockdown studies reveal impaired cell cycle regulation, increased apoptosis, and disrupted neuronal signaling, underscoring its role in maintaining cellular stability and brain function.

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