anti- 14-3-3 GAMMA-Specific antibody
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935106861
info@markelab.com
name
anti- 14-3-3 GAMMA-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00004
tested applications
ELISA, IHC, IP, WB, IF
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide |
| Host | Rabbit |
| Reactivity | human,mouse,rat,dog |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:50-1:500; IP: 1:500-1:1000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 30 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, IP, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P61981 |
| Gene ID | 7532 |
| Alias | YWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, EIEE56, DEE56 |
| Background | Antibody anti-YWHAG |
| Status | RUO |
| Note | This product is for research use only. |
YWHAG is a key adaptor protein that regulates cellular signaling by interacting with phosphorylated proteins, stabilizing complexes, and controlling their subcellular localization. It participates in pathways such as PI3K/Akt, MAPK, and p53 signaling, where it regulates cell cycle progression, apoptosis, and DNA damage response. YWHAG is highly expressed in neuronal tissues and plays essential roles in synaptic plasticity, neurogenesis, and axonal growth. It also participates in stress response pathways by stabilizing proteins involved in cellular repair and survival. Dysregulation of YWHAG has been implicated in neurodegenerative diseases, including Alzheimer’s and Huntington’s disease, where abnormal interactions lead to protein aggregation and neuronal dysfunction. Additionally, it is overexpressed in various cancers, contributing to tumor progression, resistance to apoptosis, and metastasis. Knockdown studies reveal impaired cell cycle regulation, increased apoptosis, and disrupted neuronal signaling, underscoring its role in maintaining cellular stability and brain function.
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