Gastrin-Releasing Peptide (GRP) Antibody
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Description
GRP Antibody is a Rabbit Polyclonal antibody against GRP. This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Gastrin-Releasing Peptide (GRP) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07492 |
| Gene ID | 2922 |
| NCBI Accession | NP_002082.2 |
| Alias | BN,GRP-10,proGRP,preproGRP |
| Background | Antibody anti-GRP |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
GRP is a neuropeptide that acts as the mammalian equivalent of bombesin, a peptide involved in stimulating the release of gastrin and other gastrointestinal hormones GRP is primarily secreted by nerve endings in the gastrointestinal tract and pancreas, where it regulates gastric acid secretion, gastrointestinal motility, and nutrient absorption It exerts its effects by binding to the gastrin-releasing peptide receptor (GRPR), a G-protein-coupled receptor GRP plays an important role in cell proliferation, wound healing, and neural signaling in the central nervous system Dysregulated GRP expression is associated with the pathogenesis of cancers, particularly small cell lung cancer (SCLC) and prostate cancer, where it promotes tumor cell growth and metastasis GRP and its receptor are also implicated in inflammatory processes and neurological conditions, making them potential targets for cancer therapy and gastrointestinal disorders
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GRP Antibody is a Rabbit Polyclonal antibody against GRP. This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.
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