Gastrin-Releasing Peptide (GRP) Antibody

Este producto es parte de GRP - Gastrin Releasing Peptide
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312€ (60 µl)

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935106861
info@markelab.com
name
Gastrin-Releasing Peptide (GRP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004878
tested applications
IF/ICC

Description

GRP Antibody is a Rabbit Polyclonal antibody against GRP. This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Gastrin-Releasing Peptide (GRP)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
60 µl
Size 2
120 µl
Size 3
200 µl
Form
Liquid
Tested Applications
IF/ICC
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P07492
Gene ID
2922
NCBI Accession
NP_002082.2
Alias
BN,GRP-10,proGRP,preproGRP
Background
Antibody anti-GRP
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

GRP is a neuropeptide that acts as the mammalian equivalent of bombesin, a peptide involved in stimulating the release of gastrin and other gastrointestinal hormones GRP is primarily secreted by nerve endings in the gastrointestinal tract and pancreas, where it regulates gastric acid secretion, gastrointestinal motility, and nutrient absorption It exerts its effects by binding to the gastrin-releasing peptide receptor (GRPR), a G-protein-coupled receptor GRP plays an important role in cell proliferation, wound healing, and neural signaling in the central nervous system Dysregulated GRP expression is associated with the pathogenesis of cancers, particularly small cell lung cancer (SCLC) and prostate cancer, where it promotes tumor cell growth and metastasis GRP and its receptor are also implicated in inflammatory processes and neurological conditions, making them potential targets for cancer therapy and gastrointestinal disorders

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