Gastrin-Releasing Peptide (GRP) Antibody

Background

GRP is a neuropeptide that acts as the mammalian equivalent of bombesin, a peptide involved in stimulating the release of gastrin and other gastrointestinal hormones GRP is primarily secreted by nerve endings in the gastrointestinal tract and pancreas, where it regulates gastric acid secretion, gastrointestinal motility, and nutrient absorption It exerts its effects by binding to the gastrin-releasing peptide receptor (GRPR), a G-protein-coupled receptor GRP plays an important role in cell proliferation, wound healing, and neural signaling in the central nervous system Dysregulated GRP expression is associated with the pathogenesis of cancers, particularly small cell lung cancer (SCLC) and prostate cancer, where it promotes tumor cell growth and metastasis GRP and its receptor are also implicated in inflammatory processes and neurological conditions, making them potential targets for cancer therapy and gastrointestinal disorders