GRP antibody
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Description
Gastrin-releasing peptide, also known as GRP, is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, and its main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Its 148-amino acid preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27-amino acid gastrin-releasing peptide or the 10-amino acid neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | gastrin-releasing peptide (GRP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 16kd,32kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P07492 |
| Gene ID | 2922 |
| Alias | BN,GRP-10,proGRP,preproGRP |
| Background | Antibody anti-GRP |
| Status | RUO |
| Note | Mol. Weight 16 kDa, 32 kDa |
Descripción
Pro-Gastrin Releasing Peptide (ProGRP) is a precursor protein for gastrin-releasing peptide (GRP), a neuropeptide involved in a variety of physiological processes, including the regulation of gastric acid secretion, smooth muscle contraction, and pancreatic enzyme release. GRP is also known for its role in neural signaling, particularly in the central nervous system, where it modulates stress, memory, and circadian rhythm. ProGRP is a clinically significant biomarker, particularly in the diagnosis and monitoring of small cell lung cancer (SCLC), where elevated levels in serum are associated with disease presence and progression. The stability of ProGRP in circulation makes it a superior biomarker compared to GRP itself, as it provides a more reliable measure for diagnostic purposes. Beyond its use in oncology, ProGRP may play a role in gastrointestinal and neuroendocrine disorders, with its expression linked to cellular proliferation and secretion. Current research focuses on its potential as a therapeutic target in SCLC and other malignancies, as well as its broader role in neuroendocrine signaling pathways.
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Gastrin-releasing peptide, also known as GRP, is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, and its main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Its 148-amino acid preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27-amino acid gastrin-releasing peptide or the 10-amino acid neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate.
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