GAB4 / GAB2 Antibody
221€ (50 µg)
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935106861
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name
GAB4 / GAB2 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324706
tested applications
ELISA, WB, IHC
Description
GAB4/GAB2 Antibody is a Rabbit Polyclonal against GAB4/GAB2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | GAB4/GAB2 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q2WGN9, Q9UQC2 |
| Alias | GRB2-associated binder 2-like ,GAB2-like,GRB2-associated binder 4 |
| Background | Antibody anti-GAB4 |
| Status | RUO |
Descripción
GAB4 is a lesser-characterized member of the GAB family, sharing structural similarity with GAB1, GAB2, and GAB3. It acts as an adaptor protein that recruits signaling molecules like PI3K and SHP2 to receptor tyrosine kinases, activating pathways such as PI3K/Akt and MAPK. GAB4 is expressed in various tissues, including immune and epithelial cells, where it regulates cell adhesion, migration, and proliferation. Though its biological role is not as well-studied, GAB4 is suggested to contribute to immune responses, cellular differentiation, and signal transduction. Dysregulation of GAB4 may influence tumor progression and immune dysfunction, but further research is needed to elucidate its specific roles and mechanisms.
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