G Protein-Coupled Receptor 42 (gene/pseudogene) (GPR42) Antibody

Este producto es parte de FFAR - Free Fatty Acid Receptor
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221€ (50 µg)

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935106861
info@markelab.com
name
G Protein-Coupled Receptor 42 (gene/pseudogene) (GPR42) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx322838
tested applications
ELISA, IF/ICC

Description

GPR42 Antibody is a Rabbit Polyclonal against GPR42.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
G Protein-Coupled Receptor 42 (gene/pseudogene) (GPR42)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, IF/ICC
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O15529
Gene ID
2866
Alias
GPR42,FFAR1L,GPR41L,FFAR3L,G protein-coupled receptor 42 (gene/pseudogene),FFAR1L,GPR42P
Background
Antibody anti-GPR42
Status
RUO

Descripción

GPR42 is a G protein-coupled receptor closely related to free fatty acid receptor 3 (FFAR3/GPR41). It binds short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate, which are produced by gut microbiota during the fermentation of dietary fibers. GPR42 is primarily expressed in the gastrointestinal tract and adipose tissue, where it regulates energy metabolism, gut hormone secretion, and immune responses. Although its function is similar to FFAR3, GPR42 is considered a pseudogene in some individuals due to genetic variations that can inactivate its function. When active, GPR42 modulates SCFA-mediated signaling pathways, influencing insulin sensitivity, appetite regulation, and energy expenditure. Dysregulation of GPR42 signaling is associated with metabolic disorders like obesity and type 2 diabetes, where impaired SCFA signaling disrupts metabolic homeostasis. Its involvement in linking gut microbiota activity with host metabolism highlights GPR42 as a potential target for therapeutic interventions aimed at improving metabolic health and reducing obesity-related diseases.

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