G Protein-Coupled Receptor 42 (gene/pseudogene) (GPR42) Antibody
221€ (50 µg)
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Name
G Protein-Coupled Receptor 42 (gene/pseudogene) (GPR42) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx322838
Tested Applications
ELISA, IF/ICC
Description
GPR42 Antibody is a Rabbit Polyclonal against GPR42.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: G Protein-Coupled Receptor 42 (gene/pseudogene) (GPR42) Immunogen: Synthesized peptide derived from the N-terminal region of human GPR42. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15529 |
| Gene ID | 2866 |
| Alias | GPR42,FFAR1L,GPR41L,FFAR3L,G protein-coupled receptor 42 (gene/pseudogene),FFAR1L,GPR42P |
| Background | Antibody anti-GPR42 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GPR42 is a G protein-coupled receptor closely related to free fatty acid receptor 3 (FFAR3/GPR41). It binds short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate, which are produced by gut microbiota during the fermentation of dietary fibers. GPR42 is primarily expressed in the gastrointestinal tract and adipose tissue, where it regulates energy metabolism, gut hormone secretion, and immune responses. Although its function is similar to FFAR3, GPR42 is considered a pseudogene in some individuals due to genetic variations that can inactivate its function. When active, GPR42 modulates SCFA-mediated signaling pathways, influencing insulin sensitivity, appetite regulation, and energy expenditure. Dysregulation of GPR42 signaling is associated with metabolic disorders like obesity and type 2 diabetes, where impaired SCFA signaling disrupts metabolic homeostasis. Its involvement in linking gut microbiota activity with host metabolism highlights GPR42 as a potential target for therapeutic interventions aimed at improving metabolic health and reducing obesity-related diseases.
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