G-Protein Coupled Receptor 41 (GPR41) Antibody
312€ (50 µl)
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Name
G-Protein Coupled Receptor 41 (GPR41) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx215332
Tested Applications
WB
Description
GPR41 Antibody is a Rabbit Polyclonal against GPR41.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: G-Protein Coupled Receptor 41 (GPR41) Immunogen: Synthesised peptide derived from human GPR41 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Observed MW | 38 kDa |
| Purification | Purified by affinity chromatography using epitope-specific peptide. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14843 |
| Gene ID | 2865 |
| Alias | FFAR3,FFA3R,GPR41,LSSIG,G protein-coupled receptor 41,GPCR41 |
| Background | Antibody anti-FFAR3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FFAR3, or GPR41, is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. It is highly expressed in the gastrointestinal tract, adipose tissue, and autonomic nervous system, where it regulates energy metabolism, gut hormone secretion, and immune responses. FFAR3 activation enhances the release of gut peptides like peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), contributing to appetite regulation, insulin sensitivity, and glucose homeostasis. In the autonomic nervous system, FFAR3 modulates sympathetic nervous activity, influencing energy expenditure and blood pressure. Dysregulation of FFAR3 signaling is associated with obesity, type 2 diabetes, and cardiovascular diseases, as impaired SCFA signaling disrupts metabolic balance. FFAR3 also plays a role in immune function by regulating cytokine production and neutrophil activity. As a critical link between gut microbiota and host physiology, FFAR3 is a promising therapeutic target for metabolic diseases, obesity, and cardiovascular disorders.
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