Fructose-Bisphosphate Aldolase A (ALDOA) Antibody

Este producto es parte de ALDOA - Fructose-Bisphosphate Aldolase A
Fructose-Bisphosphate Aldolase A (ALDOA) Antibody

Pida mas información

935106861

info@markelab.com

Precio

292.5€ (80 µl)

Antibody anti-ALDOA

proveedor

Abbexa

reference

abx031666

Tested Applications

ELISA, WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1, 6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia.


Background

ALDOA is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate during glycolysis. It is widely expressed, particularly in muscle tissues and the brain, where it plays a crucial role in energy metabolism and ATP production. ALDOA is vital for providing energy to rapidly proliferating cells and tissues with high metabolic demands. Dysregulation of ALDOA has been associated with cancer progression, as elevated glycolytic activity (Warburg effect) fuels tumor growth. Mutations in ALDOA cause glycogen storage disease type XII, characterized by hemolytic anemia and muscle weakness due to impaired glycolytic flux. Its role in energy metabolism underscores its importance in cellular homeostasis, growth, and disease.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Fructose-Bisphosphate Aldolase A (ALDOA)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC, IF/ICC


purification

Purified Rabbit Polyclonal Antibody.


recommended dilution

WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS containing 0.09% sodium azide.


size 1

80 µl


size 2

400 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ALDOA


dry ice

No


availability

Shipped within 5-10 working days.


alias

ALDOA,ALDA


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