Fructose-Bisphosphate Aldolase A (ALDOA) Antibody
52€ (10 µg)
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Name
Fructose-Bisphosphate Aldolase A (ALDOA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx013358
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against ALDOA protein. Immunogen region is N-terminal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fructose-Bisphosphate Aldolase A (ALDOA) Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALDOA. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04075 |
| Gene ID | 226 |
| OMIM | 103850 |
| Alias | ALDOA,ALDA |
| Background | Antibody anti-ALDOA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDOA is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate during glycolysis. It is widely expressed, particularly in muscle tissues and the brain, where it plays a crucial role in energy metabolism and ATP production. ALDOA is vital for providing energy to rapidly proliferating cells and tissues with high metabolic demands. Dysregulation of ALDOA has been associated with cancer progression, as elevated glycolytic activity (Warburg effect) fuels tumor growth. Mutations in ALDOA cause glycogen storage disease type XII, characterized by hemolytic anemia and muscle weakness due to impaired glycolytic flux. Its role in energy metabolism underscores its importance in cellular homeostasis, growth, and disease.
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