Fructose-Bisphosphate Aldolase A (ALDOA) Antibody
195€ (20 µl)
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Name
Fructose-Bisphosphate Aldolase A (ALDOA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001056
Tested Applications
ELISA, WB, IF/ICC
Description
ALDOA Antibody is a Rabbit Polyclonal antibody against ALDOA. The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fructose-Bisphosphate Aldolase A (ALDOA) Immunogen: Recombinant protein corresponding to ALDOA. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 39 kDa Observed MW: 43 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04075 |
| Gene ID | 226 |
| NCBI Accession | NP_908930.1 |
| OMIM | 103850 |
| Alias | ALDOA,ALDA |
| Background | Antibody anti-ALDOA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDOA is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate during glycolysis. It is widely expressed, particularly in muscle tissues and the brain, where it plays a crucial role in energy metabolism and ATP production. ALDOA is vital for providing energy to rapidly proliferating cells and tissues with high metabolic demands. Dysregulation of ALDOA has been associated with cancer progression, as elevated glycolytic activity (Warburg effect) fuels tumor growth. Mutations in ALDOA cause glycogen storage disease type XII, characterized by hemolytic anemia and muscle weakness due to impaired glycolytic flux. Its role in energy metabolism underscores its importance in cellular homeostasis, growth, and disease.
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