Free Fatty Acid Receptor 3 (FFAR3) Antibody

Este producto es parte de FFAR - Free Fatty Acid Receptor
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221€ (50 µg)

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935106861
info@markelab.com
name
Free Fatty Acid Receptor 3 (FFAR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx325727
tested applications
ELISA, WB, IF/ICC

Description

FFAR3 Antibody is a Rabbit Polyclonal against FFAR3.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Free Fatty Acid Receptor 3 (FFAR3)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1/5000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IF/ICC
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O14843
Gene ID
2865
Alias
FFAR3,FFA3R,GPR41,LSSIG,G protein-coupled receptor 41,GPCR41
Background
Antibody anti-FFAR3
Status
RUO

Descripción

FFAR3, or GPR41, is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. It is highly expressed in the gastrointestinal tract, adipose tissue, and autonomic nervous system, where it regulates energy metabolism, gut hormone secretion, and immune responses. FFAR3 activation enhances the release of gut peptides like peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), contributing to appetite regulation, insulin sensitivity, and glucose homeostasis. In the autonomic nervous system, FFAR3 modulates sympathetic nervous activity, influencing energy expenditure and blood pressure. Dysregulation of FFAR3 signaling is associated with obesity, type 2 diabetes, and cardiovascular diseases, as impaired SCFA signaling disrupts metabolic balance. FFAR3 also plays a role in immune function by regulating cytokine production and neutrophil activity. As a critical link between gut microbiota and host physiology, FFAR3 is a promising therapeutic target for metabolic diseases, obesity, and cardiovascular disorders.

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