Fibroblast Growth Factor-basic Protein
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Description
Fibroblast Growth Factor-basic (147 a.a) Protein is a recombinant cytokine.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | FGF 2 (147 a.a.) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 16.5 kDa Sequence Fragment: 147 AA. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 1 mg |
| Form | Lyophilized Reconstitute in sterile 18MΩ-cm H2O to a concentration of at least 100 µg/ml. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 10 mM sodium phosphate, 75 mM sodium chloride, pH 7.5. |
| Availability | Shipped within 5-10 working days. |
| Storage | The lyophilized form is stable at room temperature for up to 3 weeks. It is recommended to store this product lyophilized and desiccated at -18 °C or lower. After reconstitution, store at 4 °C for up to 7 days, or at or below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09038 |
| Alias | FGF-2,Basic fibroblast growth factor,Bfgf,Heparin-binding growth factor 2 (HBGF-2),FGFB |
| Background | Protein FGF2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FGF2, also referred to as basic fibroblast growth factor (bFGF), is a growth factor involved in critical cellular processes, including angiogenesis, wound healing, and tissue repair It binds to FGF receptors (FGFRs) and activates pathways like Ras/MAPK and PI3K/AKT, which regulate cell proliferation, survival, and differentiation FGF2 is expressed in endothelial cells, fibroblasts, and smooth muscle cells, where it drives vascularization during tissue repair and development It promotes stem cell maintenance and supports neurogenesis by enhancing neuronal survival and regeneration Dysregulated FGF2 contributes to tumor growth, angiogenesis, and metastasis in cancers such as breast cancer and glioblastoma Targeting FGF2 signaling is a therapeutic strategy in cancer treatment, tissue regeneration, and ischemic conditions
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