Fibroblast Growth Factor 2 (FGF2) Antibody
383.5€ (100 µl)
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Name
Fibroblast Growth Factor 2 (FGF2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx010777
Tested Applications
ELISA, IHC
Description
FGF2 is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF2 is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of anguogenesis. Due to its basic pH, the factor is also basic FGF (bFGF). Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FGF1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fibroblast Growth Factor 2 (FGF2) Immunogen: Purified recombinant fragment of FGF2 expressed in E. coli |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | G152 |
| Observed MW | 31 kDa |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09038 |
| Gene ID | 2247 |
| NCBI Accession | NP_001997.5, NM_002006.4 |
| OMIM | 134920 |
| Alias | FGF-2,Basic fibroblast growth factor,Bfgf,Heparin-binding growth factor 2 (HBGF-2),FGFB |
| Background | Antibody anti-FGF2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FGF2, also referred to as basic fibroblast growth factor (bFGF), is a growth factor involved in critical cellular processes, including angiogenesis, wound healing, and tissue repair It binds to FGF receptors (FGFRs) and activates pathways like Ras/MAPK and PI3K/AKT, which regulate cell proliferation, survival, and differentiation FGF2 is expressed in endothelial cells, fibroblasts, and smooth muscle cells, where it drives vascularization during tissue repair and development It promotes stem cell maintenance and supports neurogenesis by enhancing neuronal survival and regeneration Dysregulated FGF2 contributes to tumor growth, angiogenesis, and metastasis in cancers such as breast cancer and glioblastoma Targeting FGF2 signaling is a therapeutic strategy in cancer treatment, tissue regeneration, and ischemic conditions
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