Fibroblast Growth Factor 2 (FGF2) Antibody

Este producto es parte de FGF2 - Fibroblast Growth Factor 2
Fibroblast Growth Factor 2 (FGF2) Antibody

Pida mas información

935106861

info@markelab.com

Precio

281.25€ (80 µl)

Antibody anti-FGF2

proveedor

Abbexa

reference

abx025602

Tested Applications

ELISA, WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

This product is currently in development. The lead time for this product may be several months. Please contact us at info@abbexa.com for an updated lead time before purchasing this product. This product is currently in development. The lead time for this product may be several months. Please contact us at info@abbexa.com for an updated lead time before purchasing this product. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq].


Background

FGF2, also referred to as basic fibroblast growth factor (bFGF), is a growth factor involved in critical cellular processes, including angiogenesis, wound healing, and tissue repair It binds to FGF receptors (FGFRs) and activates pathways like Ras/MAPK and PI3K/AKT, which regulate cell proliferation, survival, and differentiation FGF2 is expressed in endothelial cells, fibroblasts, and smooth muscle cells, where it drives vascularization during tissue repair and development It promotes stem cell maintenance and supports neurogenesis by enhancing neuronal survival and regeneration Dysregulated FGF2 contributes to tumor growth, angiogenesis, and metastasis in cancers such as breast cancer and glioblastoma Targeting FGF2 signaling is a therapeutic strategy in cancer treatment, tissue regeneration, and ischemic conditions

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Fibroblast Growth Factor 2 (FGF2)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC, IF/ICC


purification

Purified through a protein A column, followed by peptide affinity purification.


buffer

PBS containing 0.09% sodium azide.


size 1

80 µl


size 2

400 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

FGF2


dry ice

No


availability

Please enquire.


alias

FGF-2,Basic fibroblast growth factor,Bfgf,Heparin-binding growth factor 2 (HBGF-2),FGFB


NCBI accession

NP_001997.5, NM_002006.4


note

This product is for research use only.


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