Fibroblast Growth Factor 2 (FGF2) Antibody
312€ (60 µl)
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Name
Fibroblast Growth Factor 2 (FGF2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx000620
Tested Applications
WB, IHC, IF/ICC
Description
Fibroblast Growth Factor 2 (FGF2) Antibody is a Rabbit Polyclonal antibody against Fibroblast Growth Factor 2 (FGF2). The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fibroblast Growth Factor 2 (FGF2) Immunogen: Recombinant fusion protein corresponding to human FGF2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 17 kDa/21 kDa/22 kDa/30 kDa Observed MW: 20 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09038, P15655, P13109 |
| Gene ID | 2247, 14173, 54250 |
| NCBI Accession | NP_001997.5, NM_002006.4 |
| OMIM | 134920 |
| Alias | FGF-2,Basic fibroblast growth factor,Bfgf,Heparin-binding growth factor 2 (HBGF-2),FGFB |
| Background | Antibody anti-FGF2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FGF2, also referred to as basic fibroblast growth factor (bFGF), is a growth factor involved in critical cellular processes, including angiogenesis, wound healing, and tissue repair It binds to FGF receptors (FGFRs) and activates pathways like Ras/MAPK and PI3K/AKT, which regulate cell proliferation, survival, and differentiation FGF2 is expressed in endothelial cells, fibroblasts, and smooth muscle cells, where it drives vascularization during tissue repair and development It promotes stem cell maintenance and supports neurogenesis by enhancing neuronal survival and regeneration Dysregulated FGF2 contributes to tumor growth, angiogenesis, and metastasis in cancers such as breast cancer and glioblastoma Targeting FGF2 signaling is a therapeutic strategy in cancer treatment, tissue regeneration, and ischemic conditions
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