Ezrin (Phospho-Tyr146) Antibody
52€ (10 µg)
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Name
Ezrin (Phospho-Tyr146) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012576
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against Ezrin protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:Y146, M:Y146, R:Y146.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ezrin Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Ezrin around the phosphorylation site of tyrosine 146 (S-G-YP-L-S). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15311 |
| Alias | CVL,CVIL,VIL2,HEL-S-105,Cytovillin,Villin-2 |
| Background | Antibody anti-EZR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Ezrin (EZR) is a protein that serves as a linker between the plasma membrane and the actin cytoskeleton, playing a key role in maintaining cell shape, motility, and signaling EZR is involved in various cellular processes such as cell adhesion, migration, and the formation of membrane protrusions like microvilli It functions by connecting actin filaments to membrane proteins, facilitating signal transduction and helping to organize cell structures involved in processes like phagocytosis and endocytosis Ezrin is highly expressed in cells such as epithelial cells, neurons, and immune cells, where it plays a crucial role in tissue development, synaptic function, and immune responses Dysregulation of EZR activity is linked to various diseases, including cancer, where aberrant ezrin function contributes to tumor cell metastasis and invasion Additionally, EZR is involved in maintaining the integrity of the blood-brain barrier and regulating synaptic plasticity in neurons, making it essential for both neurological and immune functions
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