ER Lipid Raft Associated 2 (ERLIN2) Antibody
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Description
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ER Lipid Raft Associated 2 (ERLIN2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94905 |
| Background | Antibody anti-ERLIN2 |
| Status | RUO |
Descripción
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ERLIN2 antibody
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation(ERAD) of inositol 1,4,5-trisphosphate receptors(IP3Rs) such as ITPR1(PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex(PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex(PubMed:24217618).
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ER Lipid Raft Associated 2 (ERLIN2) Antibody
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