ERLIN2 antibody
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Description
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation(ERAD) of inositol 1,4,5-trisphosphate receptors(IP3Rs) such as ITPR1(PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex(PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex(PubMed:24217618).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ER lipid raft associated 2 (ERLIN2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 38 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O94905 |
| Gene ID | 11160 |
| Alias | Erlin-2,Endoplasmic reticulum lipid raft-associated protein 2,Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 (SPFH domain-containing protein 2),ERLIN2,C8orf2,SPFH2 |
| Background | Antibody anti-ERLIN2 |
| Status | RUO |
| Note | Mol. Weight 38 kDa |
Descripción
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