DNA fragmentation factor subunit beta (DFFB) Antibody (HRP)
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
DNA fragmentation factor subunit beta (DFFB) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx341672
Tested Applications
ELISA
Description
DNA fragmentation factor subunit beta (DFFB) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human DFFB.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DNA fragmentation factor subunit beta (DFFB) Immunogen: Recombinant Human DNA fragmentation factor subunit beta protein (108-219AA ) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O76075 |
| Alias | DFFB, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), CAD, CPAN, DFF-40, DFF2, DFF40, DNA fragmentation factor subunit beta |
| Background | Antibody anti-DFFB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DNA fragmentation factor subunit beta (DFFB) is an essential component of the apoptotic machinery, functioning as a part of the DNA fragmentation factor (DFF) complex. DFFB forms a heterodimer with its partner subunit, DNA fragmentation factor subunit alpha (DFFA). This beta subunit possesses the enzymatic activity required for the cleavage of DNA into nucleosomal fragments, a hallmark of apoptosis. DFFB, a caspase-activated DNase, is kept in an inactive state by its binding to DFFA until caspases, triggered by apoptotic signals, cleave DFFA, releasing DFFB to execute its DNase function. Dysregulation of DFFB activity is associated with pathological conditions, including resistance to apoptosis in cancer and excessive cell death in degenerative diseases. DFFB activity is tightly regulated to ensure its apoptotic function is confined to specific cellular contexts.
Productos relacionados
DNA Fragmentation Factor Subunit Beta (DFFB) Antibody
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic pr…
Ver producto
Human Caspase Activated DNase (DFFB) Protein
Human Caspase Activated DNase (DFFB) Protein is a recombinant Human protein expressed in E. coli.…
Ver producto
Caspase Activated DNase (DFFB) Antibody
Caspase Activated DNase (DFFB) Antibody is a Polyclonal Antibody against Caspase Activated DNase (DFFB).…
Ver producto