DNA Fragmentation Factor Subunit Beta (DFFB) Antibody

Name: DNA Fragmentation Factor Subunit Beta (DFFB) Antibody
Brand: Abbexa
SKU: abx136020
Price: 195 EUR
Availability: OnlineOnly

Este producto es parte de DFFB - DNA fragmentation factor subunit beta

Pida mas información

935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-DFFB

proveedor

Abbexa

reference

abx136020

Tested Applications

ELISA, WB, IHC

reactivity

Human, Mouse

status

RUO

clonality

Polyclonal

Descripción

DFFB Antibody is a Rabbit Polyclonal against DFFB.

Background

DNA fragmentation factor subunit beta (DFFB) is an essential component of the apoptotic machinery, functioning as a part of the DNA fragmentation factor (DFF) complex. DFFB forms a heterodimer with its partner subunit, DNA fragmentation factor subunit alpha (DFFA). This beta subunit possesses the enzymatic activity required for the cleavage of DNA into nucleosomal fragments, a hallmark of apoptosis. DFFB, a caspase-activated DNase, is kept in an inactive state by its binding to DFFA until caspases, triggered by apoptotic signals, cleave DFFA, releasing DFFB to execute its DNase function. Dysregulation of DFFB activity is associated with pathological conditions, including resistance to apoptosis in cancer and excessive cell death in degenerative diseases. DFFB activity is tightly regulated to ensure its apoptotic function is confined to specific cellular contexts.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

DNA Fragmentation Factor Subunit Beta (DFFB)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC

purification

Purified by affinity chromatography.

recommended dilution

ELISA: 1 µg/ml, WB: 1/200 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

size 1

20 µl

size 2

100 µl

size 3

2 × 100 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

DFFB

dry ice

availability

Shipped within 5-10 working days.

alias

DFFB, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), CAD, CPAN, DFF-40, DFF2, DFF40, DNA fragmentation factor subunit beta

uniprot id

https://www.uniprot.org/uniprotkb/O76075

gene id

https://www.ncbi.nlm.nih.gov/gene/1677

NCBI accession

NP_004393.1

note

Concentration: > 0.2 mg/ml -

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