Coronin 1C (CORO1C) Antibody
292.5€ (80 µl)
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Name
Coronin 1C (CORO1C) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx030484
Tested Applications
ELISA, WB
Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Coronin 1C (CORO1C) Immunogen: KLH-conjugated synthetic peptide between 377-403 amino acids from the C-terminal region of human CORO1C. |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 53.2 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULV4 |
| Alias | HCRNN4,Coronin-3,Coronin-1C,CRN2,CRNN4 |
| Background | Antibody anti-CORO1C |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Coronin 1C (CORO1C) is another member of the coronin protein family with a role in regulating actin filament dynamics. Like CORO1A and CORO1B, CORO1C plays a crucial role in cellular processes such as actin-based movement, endocytosis, and cytokinesis. However, CORO1C is particularly important in the regulation of the immune system, where it modulates the signaling pathways of immune cells, including T cells, and contributes to the response to inflammation. It is also involved in maintaining the structural integrity of immune synapses, which are crucial for the communication between immune cells. Similar to the other coronins, CORO1C's dysregulation can impair immune function and has been associated with conditions that affect immune responses. Understanding the role of CORO1C in immune cell signaling and actin dynamics is critical for advancing therapeutic strategies targeting immune-related diseases.
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