CSTF3 antibody
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935106861
info@markelab.com
name
CSTF3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02040
tested applications
ELISA, WB
Description
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa (CSTF3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 77-83 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q12996 |
| Gene ID | 1479 |
| Alias | CSTF-77,CF-1 77 kDa subunit,Cleavage stimulation factor 77 kDa subunit |
| Background | Antibody anti-CSTF3 |
| Status | RUO |
| Note | Mol. Weight 77-83 kDa |
Descripción
Cleavage stimulation factor subunit 3 (CSTF3) is another essential element of the CstF complex, playing a vital role in 3' end cleavage and polyadenylation of pre-mRNAs, a process critical for mRNA maturation, stability, and export. CSTF3 functions as a homodimer and interacts with CSTF1 and CSTF2 to form the fully functional CstF complex, which participates in the recognition of cleavage sites on pre-mRNAs. It contains WD40 domains that facilitate protein-protein interactions, ensuring the stability and activity of the complex during the 3' end processing. CSTF3 is ubiquitously expressed across various tissues, highlighting its fundamental role in mRNA biogenesis. The CSTF3 gene undergoes alternative splicing, resulting in multiple transcript variants that encode different isoforms, potentially adapting its function to specific cellular contexts. CSTF3 not only participates in global mRNA processing but is also implicated in regulating alternative polyadenylation, which contributes to transcript diversity and gene expression regulation in response to developmental cues and external stimuli. Its broad expression and functional versatility emphasize its critical involvement in RNA metabolism.
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