Cleavage Stimulation Factor Subunit 1 (CSTF1) Antibody
364€ (100 µg)
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935106861
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name
Cleavage Stimulation Factor Subunit 1 (CSTF1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx232038
tested applications
ELISA, WB, IP
Description
CSTF1 Antibody is a Rabbit Polyclonal against CSTF1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cleavage Stimulation Factor Subunit 1 (CSTF1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q05048 |
| Gene ID | 1477 |
| OMIM | 600369 |
| Alias | CstF-50,CstFp50,CF-1 50 kDa subunit,Cleavage stimulation factor 50 kDa subunit |
| Background | Antibody anti-CSTF1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Cleavage stimulation factor subunit 1 (CSTF1) is a component of the cleavage stimulation factor (CstF) complex, which is crucial for the polyadenylation and 3' end cleavage of pre-mRNAs. CSTF1 contains transducin-like WD40 repeats and functions as a homodimer within the CstF complex. It interacts directly with CSTF2 and CSTF3 to form the heterotrimeric CstF complex, which assembles on the pre-mRNA to facilitate cleavage and subsequent polyadenylation. CSTF1 is responsible for mediating interactions between CstF and other factors, ensuring the formation of a stable complex on the pre-mRNA. The expression levels of CstF components, including CSTF1, vary during the cell cycle, increasing significantly during the transition from G0 to S phase, indicating a role in cell cycle-regulated mRNA processing. Additionally, CSTF1 has been shown to interact with BARD1, linking mRNA 3' end formation to DNA damage response and tumor suppression pathways.
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