Cleavage Stimulation Factor Subunit 1 (CSTF1) Antibody
195€ (20 µl)
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Name
Cleavage Stimulation Factor Subunit 1 (CSTF1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx004532
Tested Applications
ELISA, WB, IHC
Description
CSTF1 Antibody is a Rabbit Polyclonal antibody against CSTF1. This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cleavage Stimulation Factor Subunit 1 (CSTF1) Immunogen: Recombinant protein corresponding to CSTF1. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/100 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 48 kDa Observed MW: 50 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q05048 |
| Gene ID | 1477 |
| NCBI Accession | NP_001315.1 |
| Alias | CstF-50,CstFp50,CF-1 50 kDa subunit,Cleavage stimulation factor 50 kDa subunit |
| Background | Antibody anti-CSTF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Cleavage stimulation factor subunit 1 (CSTF1) is a component of the cleavage stimulation factor (CstF) complex, which is crucial for the polyadenylation and 3' end cleavage of pre-mRNAs. CSTF1 contains transducin-like WD40 repeats and functions as a homodimer within the CstF complex. It interacts directly with CSTF2 and CSTF3 to form the heterotrimeric CstF complex, which assembles on the pre-mRNA to facilitate cleavage and subsequent polyadenylation. CSTF1 is responsible for mediating interactions between CstF and other factors, ensuring the formation of a stable complex on the pre-mRNA. The expression levels of CstF components, including CSTF1, vary during the cell cycle, increasing significantly during the transition from G0 to S phase, indicating a role in cell cycle-regulated mRNA processing. Additionally, CSTF1 has been shown to interact with BARD1, linking mRNA 3' end formation to DNA damage response and tumor suppression pathways.
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