Cleavage Stimulation Factor Subunit 1 (CSTF1) Antibody
52€ (10 µg)
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935106861
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name
Cleavage Stimulation Factor Subunit 1 (CSTF1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013580
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against CSTF1 protein. Immunogen region is N-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cleavage Stimulation Factor Subunit 1 (CSTF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q05048 |
| Alias | CstF-50,CstFp50,CF-1 50 kDa subunit,Cleavage stimulation factor 50 kDa subunit |
| Background | Antibody anti-CSTF1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Cleavage stimulation factor subunit 1 (CSTF1) is a component of the cleavage stimulation factor (CstF) complex, which is crucial for the polyadenylation and 3' end cleavage of pre-mRNAs. CSTF1 contains transducin-like WD40 repeats and functions as a homodimer within the CstF complex. It interacts directly with CSTF2 and CSTF3 to form the heterotrimeric CstF complex, which assembles on the pre-mRNA to facilitate cleavage and subsequent polyadenylation. CSTF1 is responsible for mediating interactions between CstF and other factors, ensuring the formation of a stable complex on the pre-mRNA. The expression levels of CstF components, including CSTF1, vary during the cell cycle, increasing significantly during the transition from G0 to S phase, indicating a role in cell cycle-regulated mRNA processing. Additionally, CSTF1 has been shown to interact with BARD1, linking mRNA 3' end formation to DNA damage response and tumor suppression pathways.
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