Chicken Prostaglandin E synthase 3 (PTGES3) ELISA Kit
715€ (96 tests)
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935106861
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name
Chicken Prostaglandin E synthase 3 (PTGES3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx514757
tested applications
ELISA
Description
Chicken Prostaglandin E synthase 3 (PTGES3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Chicken Prostaglandin E synthase 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Prostaglandin E synthase 3 (PTGES3) |
| Reactivity | Chicken |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q90955 |
| Alias | P23,TEBP,cPGES,Progesterone receptor complex p23,Telomerase-binding protein p23 |
| Background | Elisa kits for PTGES3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Prostaglandin E synthase 3 (PTGES3), also known as p23, is a multifunctional protein that acts as a co-chaperone for heat shock protein 90 (HSP90), playing a crucial role in the stabilization and activity of various client proteins, including steroid hormone receptors and kinases. It catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), a lipid mediator involved in inflammation, immune response, and various physiological processes such as fever, pain, and vascular homeostasis. PTGES3 is also essential for the proper functioning of the glucocorticoid receptor complex, regulating its maturation and nuclear translocation. Dysregulation of PTGES3 expression has been implicated in cancer progression, as it influences tumor growth, angiogenesis, and immune evasion through PGE2-mediated signaling pathways. In addition to its roles in prostaglandin biosynthesis and HSP90 client protein stabilization, PTGES3 has been associated with the regulation of transcriptional activity and cellular stress responses, underscoring its diverse biological functions. Its expression is tightly regulated and can be modulated by cellular stress, hormonal signals, and inflammatory stimuli, highlighting its importance in maintaining cellular homeostasis and responding to external cues.
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Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2(PGH2) to prostaglandin E2(PGE2)(PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway(PubMed:24711448).
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