CD243 Antibody

429€ (100 tests)
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935106861
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name
CD243 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140461
tested applications
FCM
Description
CD243 Antibody is a Mouse Monoclonal against CD243.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | CD243 |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | APC |
Isotype | IgG2a Kappa |
Clone ID | I788 |
Size 1 | 100 tests |
Tested Applications | FCM |
Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
Availability | Shipped within 5-12 working days. |
Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
Dry Ice | No |
UniProt ID | P08183 |
Gene ID | 5243 |
Alias | ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170 |
Background | Antibody anti-ABCB1 |
Status | RUO |
Descripción
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
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