Mouse ATP-Dependent Translocase ABCB1 (ABCB1) Protein
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935106861
info@markelab.com
Precio
2795€ (1 mg)
Protein ABCB1
proveedor
Abbexareference
abx068472Tested Applications
ELISA, WB, IP, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse ATP-Dependent Translocase ABCB1 (ABCB1) Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
ATP-Dependent Translocase ABCB1 (ABCB1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
ELISA, WB, IP, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Molecular Weight: Calculated MW: 29.7 kDa Observed MW: 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu391-Thr627 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCB1
dry ice
No
availability
Shipped within 5-7 working days.
alias
ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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