C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody

Este producto es parte de CLEC7A - C-type lectin domain containing 7A
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260€ (50 µl)

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935106861
info@markelab.com
name
C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212328
tested applications
ELISA, WB, IHC

Description

CLEC7A Antibody is a Rabbit Polyclonal against CLEC7A.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
C-Type Lectin Domain Family 7, Member A (CLEC7A)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9BXN2
Gene ID
64581
Alias
Beta-glucan receptor,BGR,CD369,CANDF4,SCARE2,DECTIN1,CLECSF12,C-type lectin superfamily member 12,Dendritic cell-associated C-type lectin 1
Background
Antibody anti-CLEC7A
Status
RUO

Descripción

CLEC7A, also known as C-type lectin domain-containing protein 7A or Dectin-1, is a receptor mainly expressed on myeloid cells, especially dendritic cells, macrophages, neutrophils, and subsets of monocytes. As part of the C-type lectin receptor (CLR) family, CLEC7A is essential for recognizing pathogenic fungi, bacteria, and other microbial structures, making it a crucial component of the innate immune system. CLEC7A identifies β-glucans, polysaccharides found abundantly in fungal cell walls, and this interaction triggers immune responses, including phagocytosis and cytokine production. In addition to microbial defense, CLEC7A has roles in modulating sterile inflammatory responses, which link it to several inflammatory and autoimmune diseases. CLEC7A is predominantly studied for its role in antifungal immunity, particularly in recognizing β-1,3-glucan, a prominent component of fungal cell walls, leading to immune activation that aids in pathogen elimination. Because CLEC7A mediates signaling independently of other pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), it provides a unique and essential pathway in immunity. Its function also encompasses regulating immune responses to ensure that inflammation does not persist unnecessarily, as this can lead to tissue damage and chronic inflammatory states.

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