Family main features
CLEC7A, also known as C-type lectin domain-containing protein 7A or Dectin-1, is a receptor mainly expressed on myeloid cells, especially dendritic cells, macrophages, neutrophils, and subsets of monocytes. As part of the C-type lectin receptor (CLR) family, CLEC7A is essential for recognizing pathogenic fungi, bacteria, and other microbial structures, making it a crucial component of the innate immune system. CLEC7A identifies β-glucans, polysaccharides found abundantly in fungal cell walls, and this interaction triggers immune responses, including phagocytosis and cytokine production. In addition to microbial defense, CLEC7A has roles in modulating sterile inflammatory responses, which link it to several inflammatory and autoimmune diseases.
CLEC7A is predominantly studied for its role in antifungal immunity, particularly in recognizing β-1,3-glucan, a prominent component of fungal cell walls, leading to immune activation that aids in pathogen elimination. Because CLEC7A mediates signaling independently of other pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), it provides a unique and essential pathway in immunity. Its function also encompasses regulating immune responses to ensure that inflammation does not persist unnecessarily, as this can lead to tissue damage and chronic inflammatory states.
The structure of CLEC7A is integral to its function in immune recognition and signaling:
Extracellular C-type Lectin-like Domain (CTLD):
Stalk and Neck Region:
Transmembrane Domain:
Cytoplasmic Tail:
CLEC7A is classified under the C-type lectin receptor family, specifically within the group of dectin-like receptors, which are involved in immune recognition and host defense. It is closely related to other CLRs such as CLEC6A (Dectin-2) and CLEC4E (Mincle), which also play roles in recognizing microbial components. Unlike some other CLRs, CLEC7A does not have major subtypes or isoforms, as its primary function and ligand specificity are highly conserved. However, differences in CLEC7A expression across immune cell types provide functional diversity within immune responses.
The role of CLEC7A in immunity extends across several key functions:
Pathogen Recognition and Immune Activation:
Phagocytosis and Reactive Oxygen Species (ROS) Production:
T-helper Cell Polarization:
Regulation of Sterile Inflammation:
Fungal Infections:
Autoimmune and Inflammatory Diseases:
Cancer:
Therapeutic Targeting:
CLEC7A, or Dectin-1, is a crucial receptor in the innate immune system that detects fungal and bacterial pathogens through its C-type lectin-like domain, which binds to β-glucan. This receptor’s unique structure includes an extracellular CTLD for ligand recognition, a transmembrane region for membrane anchoring, and a cytoplasmic tail with an ITAM-like motif essential for initiating intracellular signaling. CLEC7A activation results in the production of pro-inflammatory cytokines, phagocytosis, and ROS generation, all of which are critical for pathogen clearance.
The biological significance of CLEC7A is highlighted in antifungal immunity, where it triggers immune responses against fungal pathogens, supports Th17 cell responses, and participates in sterile inflammation. Clinically, CLEC7A’s function is associated with susceptibility to fungal infections, and its dysregulation is linked to autoimmune and inflammatory diseases. CLEC7A’s role in immune regulation and pathogen recognition makes it a promising therapeutic target for enhancing immune responses in fungal infections and modulating inflammation in autoimmune conditions.
C-type lectin domain containing 7A (CLEC7A)
Beta-glucan receptor,BGR,CD369,CANDF4,SCARE2,DECTIN1,CLECSF12,C-type lectin superfamily member 12,Dendritic cell-associated C-type lectin 1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, ELISA Kits, Primary Antibodies) relacionados con CLEC7A - C-type lectin domain containing 7A
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 27 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC7A | abx495918 | Human C-Type Lectin Domain Family 7, Member A (CLEC7A) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.064 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | CLEC7A | abx258649 | Human C-Type Lectin Domain Family 7, Member A (CLEC7A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | Q9BXN2 | RUO |
Abbexa | CLEC7A | abx258650 | Mouse C-Type Lectin Domain Family 7, Member A (CLEC7A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 700 | 96 tests | RUO | |
Abbexa | CLEC7A | abx495919 | Mouse C-Type Lectin Domain Family 7, Member A (CLEC7A) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.056 ng/ml | 837.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC7A | abx414801 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (FITC) | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7, Member A (CLEC7A) | FITC | FCM | 175 | 25 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx347185 | C-type Lectin Domain Family 7 Member A (CLEC7A) Antibody (PE) | Human | Monoclonal | Mouse | C-type Lectin Domain Family 7 Member A (CLEC7A) | PE | FCM | 400 | 100 tests | RUO | ||
Abbexa | CLEC7A | abx316597 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (HRP) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 7, Member A (CLEC7A) | HRP | ELISA | 162.5 | 20 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx414803 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (PE) | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7, Member A (CLEC7A) | PE | FCM | 487.5 | 100 tests | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx414799 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | FCM | 737.5 | 500 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx414802 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | FCM | 337.5 | 100 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx316598 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (FITC) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 7, Member A (CLEC7A) | FITC | 162.5 | 20 µg | Q9BXN2 | RUO | ||
Abbexa | CLEC7A | abx302323 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx414807 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | FCM | 337.5 | 100 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx414808 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (PE) | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7, Member A (CLEC7A) | PE | FCM | 487.5 | 100 tests | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx316599 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (Biotin) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Biotin | ELISA | 162.5 | 20 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx414805 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | FCM | 462.5 | 200 µg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx140899 | C-Type Lectin Domain Family 7 Member A (CLEC7A) Antibody | Human | Monoclonal | Mouse | C-Type Lectin Domain Family 7 Member A (CLEC7A) | Unconjugated | IHC-F, FCM | 287.5 | 0.1 mg | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx212328 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx135827 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | WB | 175 | 20 µl | Q9BXN2 | RUO | |
Abbexa | CLEC7A | abx413972 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | IHC, FCM, IP | 862.5 | 500 µg | Q6QLQ4 | RUO | |
Abbexa | CLEC7A | abx413979 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (PE) | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 7, Member A (CLEC7A) | PE | FCM | 250 | 25 tests | Q6QLQ4 | RUO | |
Abbexa | CLEC7A | abx413971 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (Biotin) | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Biotin | FCM | 200 | 25 µg | Q6QLQ4 | RUO | |
Abbexa | CLEC7A | abx413976 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody (FITC) | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 7, Member A (CLEC7A) | FITC | FCM | 200 | 25 µg | Q6QLQ4 | RUO | |
Abbexa | CLEC7A | abx413980 | C-Type Lectin Domain Family 7, Member A (CLEC7A) Antibody | Mouse | Monoclonal | Rat | C-Type Lectin Domain Family 7, Member A (CLEC7A) | Unconjugated | IHC, FCM, IP | 200 | 25 µg | Q6QLQ4 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC7A | abx693811 | Human C-Type Lectin Domain Family 7, Member A (CLEC7A) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 1050 | 100 µg | RUO | ||
Abbexa | CLEC7A | abx680138 | Human C-Type Lectin Domain Family 7 Member A (CLEC7A) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | CLEC7A | abx693282 | Mouse C-Type Lectin Domain Family 7, Member A (CLEC7A) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.