C-Type Lectin Domain Family 7 Member A (CLEC7A) Antibody
312€ (0.1 mg)
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935106861
info@markelab.com
name
C-Type Lectin Domain Family 7 Member A (CLEC7A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140899
tested applications
IHC, FCM
Description
C-Type Lectin Domain Family 7 Member A (CLEC7A) Antibody is a Mouse Monoclonal against C-Type Lectin Domain Family 7 Member A (CLEC7A).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | C-Type Lectin Domain Family 7 Member A (CLEC7A) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 2-5 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a Kappa |
| Clone ID | M128 |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q9BXN2 |
| Gene ID | 64581 |
| Alias | Beta-glucan receptor,BGR,CD369,CANDF4,SCARE2,DECTIN1,CLECSF12,C-type lectin superfamily member 12,Dendritic cell-associated C-type lectin 1 |
| Background | Antibody anti-CLEC7A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
CLEC7A, also known as C-type lectin domain-containing protein 7A or Dectin-1, is a receptor mainly expressed on myeloid cells, especially dendritic cells, macrophages, neutrophils, and subsets of monocytes. As part of the C-type lectin receptor (CLR) family, CLEC7A is essential for recognizing pathogenic fungi, bacteria, and other microbial structures, making it a crucial component of the innate immune system. CLEC7A identifies β-glucans, polysaccharides found abundantly in fungal cell walls, and this interaction triggers immune responses, including phagocytosis and cytokine production. In addition to microbial defense, CLEC7A has roles in modulating sterile inflammatory responses, which link it to several inflammatory and autoimmune diseases. CLEC7A is predominantly studied for its role in antifungal immunity, particularly in recognizing β-1,3-glucan, a prominent component of fungal cell walls, leading to immune activation that aids in pathogen elimination. Because CLEC7A mediates signaling independently of other pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), it provides a unique and essential pathway in immunity. Its function also encompasses regulating immune responses to ensure that inflammation does not persist unnecessarily, as this can lead to tissue damage and chronic inflammatory states.
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