B-Cell Linker Protein (BLNK) Antibody (HRP)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
B-Cell Linker Protein (BLNK) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx317561
Tested Applications
ELISA
Description
BLNK Antibody (HRP) is a Rabbit Polyclonal against BLNK conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: B-Cell Linker Protein (BLNK) Immunogen: Recombinant Human B-cell linker protein (41-337AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WV28 |
| Gene ID | 29760 |
| NCBI Accession | NP_001107566.1, NM_001114094.1, NP_001245369.1, NM_001258440.1, NP_037446.1, NM_013314.3 |
| OMIM | 604515 |
| Alias | BLNK, AGM4, BASH, BLNK-S, LY57,B-cell adapter containing a SH2 domain protein,Cytoplasmic adapter protein |
| Background | Antibody anti-BLNK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BLNK (B-cell linker) is an adaptor protein primarily expressed in B cells, where it plays a crucial role in regulating B cell receptor (BCR) signaling. It functions by linking various signaling molecules, which is critical for the proper activation, differentiation, and survival of B cells. Upon BCR engagement, BLNK is phosphorylated, leading to the recruitment of other signaling proteins, including those involved in the activation of key pathways such as the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. This allows BLNK to help orchestrate B cell activation and the immune response. It is also involved in regulating B cell proliferation and the transition from the naive to the activated state, essential for effective immune responses. Mutations in BLNK can result in immune dysfunction and are associated with immune-related diseases, including lymphoid malignancies. Understanding its role in B cell signaling can help inform therapies for diseases involving B cells, such as autoimmune diseases and B-cell malignancies.
Productos relacionados
B-Cell Linker Protein (BLNK) Antibody
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein…
Ver producto
B-Cell Linker Protein Phospho-Tyr84 (BLNK pY84) Antibody
Rabbit polyclonal antibody against BLNK protein. Immunogen region is Internal. Specificity is as follows for the reactiv…
Ver producto
B-Cell Linker Protein (BLNK) Antibody
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein…
Ver producto