ATP-Dependent Translocase ABCB1 (ABCB1) Antibody (HRP)
169€ (20 µg)
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935106861
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name
ATP-Dependent Translocase ABCB1 (ABCB1) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx108517
tested applications
ELISA
Description
P-glycoprotein 1 Antibody (HRP) is a Rabbit Polyclonal antibody against P-glycoprotein 1 conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-Dependent Translocase ABCB1 (ABCB1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08183 |
| Gene ID | 5243 |
| NCBI Accession | NP_000918.2, NM_000927.4 |
| OMIM | 171050 |
| Alias | ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170 |
| Background | Antibody anti-ABCB1 |
| Status | RUO |
Descripción
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
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