ATP-Dependent Translocase ABCB1 (ABCB1) Antibody
299€ (50 µl)
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935106861
info@markelab.com
name
ATP-Dependent Translocase ABCB1 (ABCB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx402579
tested applications
ELISA, IHC, IF/ICC
Description
ATP-Dependent Translocase ABCB1 (ABCB1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human ABCB1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-Dependent Translocase ABCB1 (ABCB1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08183 |
| Alias | ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170 |
| Background | Antibody anti-ABCB1 |
| Status | RUO |
Descripción
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
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