ATP-Binding Cassette Sub-Family D Member 3 (ABCD3) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
ATP-Binding Cassette Sub-Family D Member 3 (ABCD3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx038197
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ABCD3 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-Binding Cassette Sub-Family D Member 3 (ABCD3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28288 |
| Gene ID | 5825 |
| NCBI Accession | NP_002849.1, NM_002858 |
| OMIM | 170995 |
| Alias | ABC43,CBAS5,PMP70 |
| Background | Antibody anti-ABCD3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ABCD3, also known as PMP70, is a critical peroxisomal transporter involved in the import of a broad range of substrates, including bile acid intermediates, branched-chain fatty acids, and very-long-chain fatty acids (VLCFAs). It facilitates the transport of these molecules into peroxisomes, where they undergo β-oxidation or other metabolic processes. ABCD3 is highly expressed in tissues such as the liver, kidneys, and adrenal glands, reflecting its role in maintaining lipid homeostasis and detoxification. Mutations or dysregulation of ABCD3 can result in impaired peroxisomal function, contributing to disorders such as Zellweger spectrum disorders, characterized by defects in peroxisomal metabolism. ABCD3’s role in lipid transport underscores its significance in metabolic and developmental processes.
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