Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 3 (AGAP3) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 3 (AGAP3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037786
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AGAP3 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 3 (AGAP3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001042535.1 |
| Alias | AGAP-3,CENTG3,CRAG |
| Background | Antibody anti-AGAP3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
AGAP3 is a multifunctional protein involved in vesicle trafficking, cytoskeletal organization, and intracellular signaling pathways. Structurally, it contains a GTPase-activating protein (GAP) domain, ankyrin repeats, and a pleckstrin homology (PH) domain, which mediate its interactions with small GTPases, particularly Arf proteins, and enable membrane association. AGAP3 plays a role in endosomal transport, receptor recycling, and the regulation of cytoskeletal dynamics, with a particular impact on processes like cell migration and neuronal signaling. It is expressed in various tissues, including the nervous system, where it influences synaptic plasticity and vesicle formation. Dysregulation of AGAP3 has been implicated in cancer progression, as it enhances cell motility and survival, and in neurological disorders where it affects cellular transport and signaling.
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