Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 3 (AGAP3) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 3 (AGAP3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029473
tested applications
ELISA, WB
Description
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Arf-GAP With GTPase, ANK Repeat And PH Domain-Containing Protein 3 (AGAP3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96P47 |
| Alias | AGAP-3,CENTG3,CRAG |
| Background | Antibody anti-AGAP3 |
| Status | RUO |
Descripción
AGAP3 is a multifunctional protein involved in vesicle trafficking, cytoskeletal organization, and intracellular signaling pathways. Structurally, it contains a GTPase-activating protein (GAP) domain, ankyrin repeats, and a pleckstrin homology (PH) domain, which mediate its interactions with small GTPases, particularly Arf proteins, and enable membrane association. AGAP3 plays a role in endosomal transport, receptor recycling, and the regulation of cytoskeletal dynamics, with a particular impact on processes like cell migration and neuronal signaling. It is expressed in various tissues, including the nervous system, where it influences synaptic plasticity and vesicle formation. Dysregulation of AGAP3 has been implicated in cancer progression, as it enhances cell motility and survival, and in neurological disorders where it affects cellular transport and signaling.
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