Apoptosis Inducing Factor (AIF) Antibody
273€ (100 µl)
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Name
Apoptosis Inducing Factor (AIF) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx102410
Tested Applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Apoptosis Inducing Factor (AIF).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis Inducing Factor (AIF) Immunogen: AIF (Gly103-Lys322) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95831 |
| Alias | AIFM1,AIF,PDCD8 |
| Background | Antibody anti-AIF |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Apoptosis Inducing Factor (AIF) is a mitochondrial flavoprotein that plays a dual role in cellular processes, including apoptosis and redox homeostasis. Under normal conditions, AIF resides in the mitochondria, where it participates in oxidative phosphorylation and protects against reactive oxygen species (ROS). During apoptotic signaling, AIF translocates from the mitochondria to the nucleus, where it triggers chromatin condensation and large-scale DNA fragmentation in a caspase-independent manner. This makes AIF a key mediator of programmed cell death in response to mitochondrial dysfunction or oxidative stress. Dysregulation of AIF is implicated in neurodegenerative diseases, such as Parkinson's and Alzheimer's, where mitochondrial dysfunction and cell death contribute to disease progression. Additionally, AIF mutations have been linked to mitochondrial encephalomyopathy and other metabolic disorders. Targeting AIF-related pathways is being explored as a therapeutic strategy for conditions involving excessive cell death or mitochondrial dysfunction.
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