Family main features
Apoptosis-Inducing Factor (AIF) plays a significant role in apoptosis, also known as programmed cell death. AIF is primarily located in the mitochondria. It is involved in the regulation of apoptosis through both caspase-dependent and caspase-independent pathways. While most apoptotic pathways involve the activation of caspase enzymes, AIF-mediated apoptosis occurs independently of caspases. In Caspase-Independent Apoptosis, AIF-mediated apoptosis is triggered by various cellular stresses, such as DNA damage, oxidative stress, or toxins. In response to these stresses, AIF is released from the mitochondria into the cytoplasm. Once in the cytoplasm, AIF translocates to the nucleus where it induces chromatin condensation and DNA fragmentation, ultimately leading to cell death. AIF has been also implicated in several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and Huntington's disease. Dysregulation of AIF-mediated apoptosis has been observed in the pathogenesis of these diseases, suggesting that targeting AIF could potentially be a therapeutic strategy. AIF also plays a role in maintaining mitochondrial function and integrity. It is involved in processes such as mitochondrial biogenesis and electron transport chain regulation.
Apoptosis Inducing Factor (AIF) is a critical protein involved in caspase-independent apoptosis and mitochondrial function. It plays a dual role, contributing to both cell death and survival. In the mitochondria, AIF is essential for maintaining cellular energy metabolism and redox balance, while its translocation to the nucleus triggers chromatin condensation and DNA fragmentation during apoptosis. AIF's dysregulation is associated with various diseases, including neurodegenerative disorders and cancer, making it a significant focus in biomedical research. Understanding AIF's mechanisms and interactions continues to provide insights into therapeutic strategies for these conditions.
Apoptosis Inducing Factor (AIF)
AIFM1,AIF,PDCD8
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con AIF - Apoptosis Inducing Factor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 15 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | AIF | EH2606 | Human AIF(Apoptosis Inducing Factor) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O95831 | RUO | ||
Abbexa | AIF | abx196455 | Human Apoptosis Inducing Factor (AIF) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | AIF | abx190029 | Human Apoptosis Inducing Factor (AIF) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 2.74 pg/ml - 2000 pg/ml | < 1.17 pg/ml | 812.5 | 96 tests | RUO | |
FineTest | AIF | EM0826 | Mouse AIF(Apoptosis Inducing Factor) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 7.813-500pg/ml | 96T | Q9Z0X1 | RUO | ||
Abbexa | AIF | abx196725 | Mouse Apoptosis Inducing Factor (AIF) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 6.25 pg/ml - 400 pg/ml | 3.75 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | AIF | abx492375 | Rat Apoptosis Inducing Factor (AIF) CLIA Kit | Rat | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.061 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | AIF | FNab00235 | anti- AIF antibody | human | polyclonal | Rabbit | apoptosis-inducing factor, mitochondrion-associated, 1 | IgG | Unconjugated | ELISA, IHC, WB, IF | 100µg | O95831 | RUO | |
Abbexa | AIF | abx171293 | Apoptosis Inducing Factor (AIF) Antibody | Human | Monoclonal | Mouse | Apoptosis Inducing Factor (AIF) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | AIF | abx102410 | Apoptosis Inducing Factor (AIF) Antibody | Human | Polyclonal | Rabbit | Apoptosis Inducing Factor (AIF) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O95831 | RUO | |
Abbexa | AIF | abx230235 | Apoptosis Inducing Factor (AIF) Antibody | Human | Polyclonal | Rabbit | Apoptosis Inducing Factor (AIF) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | O95831 | RUO | |
Abbexa | AIF | abx011979 | Apoptosis Inducing Factor (AIF) Antibody | Human | Monoclonal | Mouse | Apoptosis Inducing Factor (AIF) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 362.5 | 100 µl | O95831 | RUO | |
Abbexa | AIF | abx175443 | Apoptosis Inducing Factor (AIF) Antibody | Rat | Polyclonal | Rabbit | Apoptosis Inducing Factor (AIF) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AIF | abx652560 | Rat Apoptosis Inducing Factor (AIF) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | AIF | abx065442 | Human Apoptosis Inducing Factor (AIF) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | O95831 | RUO |
FineTest | AIF | P4336 | Recombinant Human AIF | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | O95831-3 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.