Human Apoptosis Inducing Factor (AIF) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Apoptosis Inducing Factor (AIF) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx065442
Tested Applications
WB, SDS-PAGE
Description
Human Apoptosis Inducing Factor (AIF) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Apoptosis Inducing Factor (AIF) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gly103-Lys322 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 27.8 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95831 |
| Alias | AIFM1,AIF,PDCD8 |
| Background | Protein AIF |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Apoptosis Inducing Factor (AIF) is a mitochondrial flavoprotein that plays a dual role in cellular processes, including apoptosis and redox homeostasis. Under normal conditions, AIF resides in the mitochondria, where it participates in oxidative phosphorylation and protects against reactive oxygen species (ROS). During apoptotic signaling, AIF translocates from the mitochondria to the nucleus, where it triggers chromatin condensation and large-scale DNA fragmentation in a caspase-independent manner. This makes AIF a key mediator of programmed cell death in response to mitochondrial dysfunction or oxidative stress. Dysregulation of AIF is implicated in neurodegenerative diseases, such as Parkinson's and Alzheimer's, where mitochondrial dysfunction and cell death contribute to disease progression. Additionally, AIF mutations have been linked to mitochondrial encephalomyopathy and other metabolic disorders. Targeting AIF-related pathways is being explored as a therapeutic strategy for conditions involving excessive cell death or mitochondrial dysfunction.
Productos relacionados
Apoptosis Inducing Factor (AIF) Antibody
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondr…
Ver producto Human Apoptosis Inducing Factor (AIF) Protein
Human Apoptosis Inducing Factor (AIF) is a recombinant Human protein expressed in E. coli.…
Ver producto
Apoptosis Inducing Factor (AIF) Antibody
Polyclonal Antibody to Apoptosis Inducing Factor (AIF).…
Ver producto